life, who was looked upon as past all hope, and suspected to be suffering from some latent malignant disease, slowly but steadily recovered under the free use of brandy, but with the singular result of the hair on one side of his head turning permanently grey, whilst the other retained its original brown colour. The second case of recovery occurred in a gentleman above middle age ; it was by no means far advanced, but was sufficiently well marked to excite alarm. He left his business, quitted London, and sought recreation in the country. After a time he returned, and appeared to have shaken off the disorder almost entirely. In three cases only was there an inspection of the body after death, and in all of them was found a diseased condition of the supra-renal capsules. In two of the cases no disease whatever could be detected in any other part of the body. Dr. Addison inquired if it were possible for all this to be merely coincidental ? It might be so, but he thought not, and making every allowance for the bias and prejudice inseparable from the hope or vanity of an original discovery, he confessed that he felt it very difficult to be persuaded that it was so. On the contrary, he could not help entertaining a very strong impression that these hitherto mysterious bodies - the supra-renal capsules - may be either directly or indirectly concerned in sanguification ; and that a diseased condition of them, functional or structural, may interfere with the proper elaboration of the body generally, or of the red particles more especially. At all events, he considered that the time had arrived when he felt himself warranted in directing the attention of the profession to these curious facts. In thanking the Society for the patient hearing with which they had favoured him, he ventured to bespeak their interest not only in regard to the anæmia he had described, but also in cases of purpura, and some of the more anæmiated forms of chlorosis in the female, which he could not but regard as being more or less allied to the morbid state to which he had directed their attention. Indeed, not only had he found the anæmia in question occasionally occurring in connection with purpura, but had observed in cases of the latter disorder certain local symptoms which pointed somewhat significantly to the seat of the supra-renal capsules ; whilst the bloodless and waxy appearance of certain chlorotic females bore so close a resemblance to the anæmia described, that it was difficult not to suspect the existence of something common to both.