1.
Mr. HUTCHINSON, Path. Trans., Vol.viii., p. 341, 1857, Mr. J. ALLEN, Liverpool.

Male, 25, sailor.

Had had yellow fever in Crimea; never well afterwards; skin much tinged at time of fever, and has latterly got darker. Last illness, fourteen days.

Dyspnœa; pain in left side; dusky, bloated countenance, anxious and disturbed expression.

Entire surface more or less bronzed - face, arms, and hands least; areolæ dark, colour deepest on lower part of trunk, on scrotum and penis, and inside thighs. Under microscope, large deposit of pigment in rete mucosum.

Both quite healthy.

Pneumonic consolidation of both lungs.

2.
Dr. HARLEY, Path. Trans., vol. x., p. 264, 1858, Dr. PARKES.

Male, 66, cabman.

Jaundice seven years before, followed by darkening of skin on face, neck, and other parts; for five years, colour remained un-altered, and health good. Illness, six months.

None recorded; patient has ascites.

Face, neck, and arms dark; over trunk, and especially abdomen, colour diversified with irregular white patches; conjunctivæ slightly yellow, with a little dark pigment; a dark patch on mucous membrane of lips.

Healthy

Hob-nail liver; spleen greatly enlarged.

3.
Dr. QUAIN, Path. Trans., vol. ix., p. 412, 1858, Dr. BUCKNILL.

Female, 45, sempstress.

Had been insane five months prior to commencement of discoloration. Discoloration, nine months.

Convulsive movement of body and legs; mind weak and childish, appetite voracious; progressive emaciation. Three attacks of apoplexy; the third fatal.

Discoloration began with sallowness of face; the skin of face, arms, hands, and body, became as dark as a Mulatto`s, but with a yellow tinge; conjunctivæ very clear.

Committee of Pathological Society reported that they did not look upon the supra-renal capsules as diseased.

Healthy, excepting brain and skull.