Autopsy.- Thorax.- The left lung adherent at many points to the right side, but quite crepitant ; right lung indurated at apex, but containing no recent tubercle, and generally crepitant.
Abdomen.- Here were noticed two lesions- (1) Hardness of the left supra-renal capsule, which, on being opened, was found to be filled with a dryish, white, cheesy matter ; and (2) psoas abscess, bulging on either side of the two last dorsal and two upper lumbar vertebræ, which were much diseased by caries ; the adjoining vertebræ were soft. The right supra-renal capsule was only imperfectly removed, but from the shreds of it examined it seems to have been affected as the left. Both were sent to Dr. Addison, and examined by Dr. Wilks, pathologist at Guy’s Hospital. The following is Dr. Wilks’s account of the specimen, addressed to Dr. Addison:

“I have examined the specimen of supra-renal capsule, and it appears to be a capital example of the disease. The organ is quite destroyed by the peculiar unorganizable and cretaceous matter we have before so often seen. The matter exists in the specimen in all its stages, as if the destruction of the organ had been proceeding with the utmost possible slowness. Thus, some parts of the diseased mass, especially the edges, consist of a peculiar gray, semi-pellucid matter, of cheesy consistence, which we have hitherto looked upon as the more recent deposit, and seen especially in the acutely fatal form of the disease, or when associated with maladies elsewhere. The great bulk of it, however, consists of a material of an opaque white colour, of the same consistence as the former, and, in fact, being the same substance undergoing decay. The microscope exibits no more than usual ; that is, an almost amorphous matter, containing a few ill-formed nuclei and granules, the latter being fatty in the opaque white part. There are also scattered through it some pieces of cretaceous matter. The smaller portion, which is said to be a portion of the other capsule, consists almost entirely of this cretaceous matter. From the occasional association of this disease of the supra-renal capsules with tubercle, I imagine it right to consider it nearly allied to a scrofulous affection of the organ, and comparing this specimen with others of a like kind, and from considering the time necessary for cretaceous changes to occur in tubercular deposits, I think there can be no doubt that the disease has been of very long duration, and therefore the necessity, as you often observe, for having such cases under notice for several years, a fact which does not seem to be generally understood. It may be interesting to remember that in one of your published cases1 the spine adjacent to the capsule was diseased, and the same also occurred in another case, reported, I think, in the ‘Medical Times’ about three years ago, From St. Bartholomew’s Hospital.”

Case 18.- The following was the last case which Dr. Addison had in hospital, and he pronounced upon it at once, and almost unhesitatingly, as a most characteristic example of the disease known by his name. In the present state of