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opinion respecting this remarkable affection, I may be allowed to deviate from the strictly scientific delineation of the cases, and allude to any circumstances affecting the history of its discovery, and bearing on the probabilities of its being a truly scientific deduction or not. Thus, in the present case, I may be allowed to state, in answer to those who have hinted at the diagnosis being nothing more than a guess, that, being away from the hospital during the time this case was in the institution, I was urgently written to by Dr. Addison to have a drawing or model made of the patient ; also, that I myself wrote to Mr. Hutchinson, who was collecting cases for the ‘Medical Times and Gazette,’ informing him that he had an opportunity of seeing a model case of morbus Addisonii. Unfortunately, neither Dr. Addison’s nor my own wishes were accomplished, as the lad soon died ; but so certain was the feeling of the correctness of the diagnosis, that a special appointment was made with Mr. Towne at an early hour of the morning, in order to model the organs when removed. It was thus seen that the diagnosis was as positive and as much believed and persisted in as any opinion which was formed as to the nature of a disease can possibly be. I make these remarks in reference to Addison’s last case, in order to show that he had no doubt as to the correctness of his first conclusions.

Robert B___, æt. 13, was admitted under Dr. Addison into Guy’s Hospital, on August 17th, 1859, and died August 20th. The case was sent in by Dr. Aldis as one of supra-renal disease, and as soon as Dr. Addison saw the patient he recognised it as a very perfect example of the disease. The boy was universally discoloured, being of a yellowish-brown hue, though not so dark as had been observed in some other instances ; he was so weak as to be unable to stand, and when made to sit up in bed to undergo a physical examination of the chest, he was so feeble that he requested to be immediately laid down again, so powerless and utterly exhausted did he appear to be. Dr. Addison unhesitatingly declared his conviction of the correctness of the diagnosis, and that it was a most characteristic example of the affection.

The following is the history of the case as given by Dr. Aldis:

Robert B___, æt. 13, was admitted under my care at the Surrey Dispensary, on March 25th, 1859. The skin was tinged in every part of the body with a dark-olive colour, accompanied by nausea, occasional vomiting, great pain in the back, and prostration. He always felt languid, and disposed to lie down, which he frequently did whilst waiting to see me at the dispensary. The eyes were sunken with a dark-

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